Article
Impacts of HLA-DR3DQ2 and HLA-DR4DQ8 haplotypes singly and combined on autoimmunity, phenotype and comorbidity in patients with Latent Autoimmune Diabetes in the adult. Results from the HUNT and ESTRID studies.
Journal of autoimmunity - 1 Jun 2026
Sørgjerd Elin Pettersen, Hals Ingrid K, Lønnum Birte Ee, Edstorp Jessica, Ahlqvist Emma, Carlsson Sofia, Grill Valdemar
Abstract excerpt
BACKGROUND: The major genetic high-risk of developing autoimmune diabetes are HLA-DR3DQ2 and HLA-DR4DQ8 haplotypes. Their importance in Latent Autoimmune Diabetes in Adults (LADA) has only been partly elucidated. Here we aimed to dissect their impact on autoimmunity, diabetic phenotype, and comorbidity. METHODS: Data from individuals with LADA were collected from two all-population based surveys, the Norwegian...
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