Article
Rare Genetic Variants of NLRP12 in Admixed Latino-American Children With SARS-CoV-2-Related Multisystem Inflammatory Syndrome.
The Journal of infectious diseases - 16 Dec 2024
Barreto Thaís M M, Souza Roberta S, São Pedro Raquel B, Paiva Isadora M, Silva Andréia S, Nogueira Ana L, Bellinat Ana P N, Dias Nathália L S, Nunes Sara, Britto Gabriela S G, Amaral Edson H B, Rocha Gabriela D, Silva-Carvalho Carolina, Lyra Ricardo, Kehdy Fernanda S G, Campos Túlio L, Moura Patrícia M M F, Tarazona-Santos Eduardo, Cunha Thiago M, Tavares Natália M, Oliveira-Sá Marcus V B, Ramos Regina C F, Carmo Rodrigo F, Vasconcelos Luydson R S, Oliveira Pablo R S
Abstract excerpt
Multisystem inflammatory syndrome in children (MIS-C) is a rare, potentially fatal complication of SARS-CoV-2 infection. Genetic defects in inflammation-related pathways have been linked to MIS-C, but additional research is needed, especially in diverse ethnic groups. The present study aimed to identify genetic variants underlying MIS-C in Brazilian patients. Whole exome sequencing was performed, focusing on...
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