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Article

Identifying X-chromosome variants associated with age-related macular degeneration.

Human molecular genetics - 6 Dec 2024

Grunin Michelle, Igo Robert P, Song Yeunjoo E, Blanton Susan H, Pericak-Vance Margaret A, Haines Jonathan L

Abstract excerpt

PURPOSE: In genome-wide association studies (GWAS), X chromosome (ChrX) variants are often not investigated. Sex-specific effects and ChrX-specific quality control (QC) are needed to examine these effects. Previous GWAS identified 52 autosomal variants associated with age-related macular degeneration (AMD) via the International AMD Genomics Consortium (IAMDGC), but did not analyze ChrX. Therefore¸ our goal was to...

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Share to Aged
Share to Aged, 80 and over
Share to Chromosomes, Human, X

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Macular Degeneration

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 39324238
DOI: 10.1093/hmg/ddae141
PMCID: PMC11630753

Genes

DMD
SLITRK4
ARHGAP6
FGF13
XG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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