Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel germline Pregnane X Receptor (PXR) variant predisposing to Hodgkin lymphoma in two siblings.

European journal of medical genetics - 1 Dec 2024

Khodzhaev Khusan, Sudutan Tugce, Erbilgin Yucel, Saritas Merve, Yegen Gulcin, Bozkurt Ceyhun, Sayitoglu Muge, Kebudi Rejin

Abstract excerpt

Hodgkin's lymphoma (HL) is the most common cancer in adolescents and young adults. A family history of HL increases the risk of developing HL in other family members. Identification of genetic predisposition variants in HL is important for understanding disease aetiology, prognosis, and response to treatment. Aberrant activation of the NF-κB pathway is a hallmark feature of HL, contributing to the survival and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Hodgkin Disease

Share to Homozygote

Share to Pedigree

Share to Pregnane X Receptor

Share to Siblings

Source

Identifiers

PMID: 39322061
DOI: 10.1016/j.ejmg.2024.104975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel germline Pregnane X Receptor (PXR) variant predisposing to Hodgkin lymphoma in two siblings.PMID 39322061Read ↗

Identification of Familial Hodgkin Lymphoma Predisposing Genes Using Whole Genome SequencingSemantic proximity Read ↗

Discovery of novel predisposing coding and noncoding variants in familial Hodgkin lymphoma.Semantic proximity Read ↗

Genetic variant spectrum in 265 Chinese patients with hemophagocytic lymphohistiocytosis: Molecular analyses of PRF1, UNC13D, STX11, STXBP2, SH2D1A, and XIAP.Semantic proximity Read ↗

Clinical, Molecular, and Environmental Risk Factors for Hodgkin LymphomaSemantic proximity Read ↗

Shared genetic features between lymphoma pathogenesis and oestrogen levelsSemantic proximity Read ↗

Genetic features of late onset primary hemophagocytic lymphohistiocytosis in adolescence or adulthood.Semantic proximity Read ↗

Functional multigenic variations associated with hodgkin lymphoma.Semantic proximity Read ↗

Whole-exome sequencing identifies a CD38 variant in a Chinese family with Hodgkin’s lymphomaSemantic proximity Read ↗

Risk of familial classical Hodgkin lymphoma by relationship, histology, age, and sex: a joint study from five Nordic countries.Semantic proximity Read ↗

Familial predisposition and genetic risk factors for lymphoma.Semantic proximity Read ↗

Association between PXR polymorphisms and cancer risk: a systematic review and meta-analysis.Semantic proximity Read ↗

Risk factors for Richter syndrome in chronic lymphocytic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.