Article
Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage.
American journal of human genetics - 3 Apr 2014
Woo Daniel, Falcone Guido J, Devan William J, Brown W Mark, Biffi Alessandro, Howard Timothy D, Anderson Christopher D, Brouwers H Bart, Valant Valerie, Battey Thomas W K, Radmanesh Farid, Raffeld Miriam R, Baedorf-Kassis Sylvia, Deka Ranjan, Woo Jessica G, Martin Lisa J, Haverbusch Mary, Moomaw Charles J, Sun Guangyun, Broderick Joseph P, Flaherty Matthew L, Martini Sharyl R, Kleindorfer Dawn O, Kissela Brett, Comeau Mary E, Jagiella Jeremiasz M, Schmidt Helena, Freudenberger Paul, Pichler Alexander, Enzinger Christian, Hansen Björn M, Norrving Bo, Jimenez-Conde Jordi, Giralt-Steinhauer Eva, Elosua Roberto, Cuadrado-Godia Elisa, Soriano Carolina, Roquer Jaume, Kraft Peter, Ayres Alison M, Schwab Kristin, McCauley Jacob L, Pera Joanna, Urbanik Andrzej, Rost Natalia S, Goldstein Joshua N, Viswanathan Anand, Stögerer Eva-Maria, Tirschwell David L, Selim Magdy, Brown Devin L, Silliman Scott L, Worrall Bradford B, Meschia James F, Kidwell Chelsea S, Montaner Joan, Fernandez-Cadenas Israel, Delgado Pilar, Malik Rainer, Dichgans Martin, Greenberg Steven M, Rothwell Peter M, Lindgren Arne, Slowik Agnieszka, Schmidt Reinhold, Langefeld Carl D, Rosand Jonathan
Abstract excerpt
Intracerebral hemorrhage (ICH) is the stroke subtype with the worst prognosis and has no established acute treatment. ICH is classified as lobar or nonlobar based on the location of ruptured blood vessels within the brain. These different locations also signal different underlying vascular pathologies. Heritability estimates indicate a substantial genetic contribution to risk of ICH in both locations. We report a...
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