Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells.

Proteomics - 1 Jul 2021

Carli Annalisa L E, Afshar-Sterle Shoukat, Rai Alin, Fang Haoyun, O'Keefe Ryan, Tse Janson, Ferguson Fleur M, Gray Nathanael S, Ernst Matthias, Greening David W, Buchert Michael

Abstract excerpt

Doublecortin-like kinase 1 (DCLK1) is a putative cancer stem cell marker, a promising diagnostic and prognostic maker for malignant tumors and a proposed driver gene for gastric cancer (GC). DCLK1 overexpression in a majority of solid cancers correlates with lymph node metastases, advanced disease and overall poor-prognosis. In cancer cells, DCLK1 expression has been shown to promote epithelial-to-mesenchymal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Extracellular Vesicles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Membrane Proteins

Share to Neoplastic Stem Cells

Share to Protein Serine-Threonine Kinases

Share to Stomach Neoplasms

Share to Vesicular Transport Proteins

Source

Identifiers

PMID: 33991177
DOI: 10.1002/pmic.202000098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells.PMID 33991177Read ↗

The kinase activity of the cancer stem cell marker DCLK1 drives gastric cancer progression by reprogramming the stromal tumor landscapeSemantic proximity Read ↗

DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression.Semantic proximity Read ↗

Pleiotropic effects of DCLK1 in cancer and cancer stem cellsSemantic proximity Read ↗

Research Progress of DCLK1 Inhibitors as Cancer TherapeuticsSemantic proximity Read ↗

Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1Semantic proximity Read ↗

Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 KinaseSemantic proximity Read ↗

Comparative proteomic analysis of three major extracellular classes secreted from human adenocarcinoma and metastatic colorectal cancer cells: exosomes, microparticles and shed midbody remnantsSemantic proximity Read ↗

The microprotein HDSP promotes gastric cancer progression through activating the MECOM-SPINK1-EGFR signaling axisSemantic proximity Read ↗

AQP5 complements LGR5 to determine the fates of gastric cancer stem cells through regulating ULK1 ubiquitinationSemantic proximity Read ↗

Alternative splice variants of DCLK1 mark cancer stem cells, promote self‐renewal and drug‐resistance, and can be targeted to inhibit tumorigenesis in kidney cancerSemantic proximity Read ↗

Decellularized extracellular matrix tissues from human gastric cancer tissues as a three-dimensional model for cancer cell growth and drug treatmentsSemantic proximity Read ↗

Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.