Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer.

doi:10.1158/1078-0432.CCR-24-1164

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Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2024

Singh Harshabad, Xiu Joanne, Kapner Kevin S, Yuan Chen, Narayan Raja R, Oberley Matthew, Farrell Alex, Surana Rishi, Huffman Brandon M, Perez Kimberly, Cleary James M, Jordan Alexander C, Dias Costa Andressa, Williams Hannah L, Raghavan Srivatsan, Weinberg Benjamin, Pishvaian Michael J, Shroff Rachna T, Goel Sanjay, Dougan Stephanie K, Nowak Jonathan A, Spetzler David, Sledge George, Wolpin Brian M, Aguirre Andrew J

Abstract excerpt

PURPOSE: Transcriptional profiling of pancreatic cancers has defined two main transcriptional subtypes: classical and basal. Initial data suggest shorter survival for patients with basal tumors and differing treatment sensitivity to FOLFIRINOX and gemcitabine plus nab-paclitaxel by transcriptional subtype. EXPERIMENTAL DESIGN: We examined 8,743 patients with RNA sequencing from pancreatic cancers performed at...

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PMID: 39283131
DOI: 10.1158/1078-0432.CCR-24-1164

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