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Article

The 1400 metabolite-mediated relationship between 91 inflammatory cytokines and migraine: An exploratory two-step Mendelian randomization study.

European journal of clinical investigation - 1 Dec 2024

Sun Huiqi, Lv Xutong, Zhang Dongbin, Shen Yue, Lu Hongxiu

Abstract excerpt

BACKGROUND: Inflammatory cytokines and migraines have been associated in previous research, but the underlying mechanisms of action are still elusive. The biological functions of metabolites are crucial in the onset of migraine. Our goals were to clarify the cause-and-effect connection between inflammatory cytokines and migraines and explore the potential mediating function of metabolites. METHODS: Utilizing...

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PMID: 39279254
DOI: 10.1111/eci.14316

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