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Somatic mutations in 3929 HPV positive cervical cells associated with infection outcome and HPV type.

Nature communications - 12 Sept 2024

Pinheiro Maisa, Wentzensen Nicolas, Dean Michael, Yeager Meredith, Chen Zigui, Shastry Amulya, Boland Joseph F, Bass Sara, Burdett Laurie, Lorey Thomas, Mishra Sambit, Castle Philip E, Schiffman Mark, Burk Robert D, Zhu Bin, Mirabello Lisa

Abstract excerpt

Invasive cervical cancers (ICC), caused by HPV infections, have a heterogeneous molecular landscape. We investigate the detection, timing, and HPV type specificity of somatic mutations in 3929 HPV-positive exfoliated cervical cell samples from individuals undergoing cervical screening in the U.S. using deep targeted sequencing in ICC cases, precancers, and HPV-positive controls. We discover a subset of hotspot...

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Cervix Uteri
High-Throughput Nucleotide Sequencing
Human papillomavirus 16
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Papillomaviridae

Papillomavirus Infections

Uterine Cervical Dysplasia

Uterine Cervical Neoplasms

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Open in PubMed Open full text

Identifiers

PMID: 39266536
DOI: 10.1038/s41467-024-51713-y
PMCID: PMC11393421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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