Article
Whole-genome sequencing of 1,083 HPV45 cases and controls identifies genetic variants associated with glandular cervical lesions.
International journal of cancer - 15 Sept 2025
Koestler Aimee J, Nelson Chase W, Yeager Meredith, Chen Zigui, Mishra Sambit K, Burdett Laurie, Dean Michael, Suh-Burgmann Elizabeth, Lorey Thomas, Clifford Gary M, Wentzensen Nicolas, Castle Philip E, Schiffman Mark, Burk Robert D, Mirabello Lisa
Abstract excerpt
Human papillomavirus type 45 (HPV45) causes ~6% of all cervical cancers and an even greater proportion of adenocarcinomas, the latter of which are challenging to detect using current cervical cancer screening. Little is known about how HPV45 genetic variation is related to the risk of cervical precancer/cancer. To investigate this, we whole-genome sequenced a total of 1,083 HPV45-positive samples from two large...
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