Comparing the Diagnostic Yield of Germline Exome Versus Panel Sequencing in the Diverse Population of the Texas KidsCanSeq Pediatric Cancer Study.

doi:10.1200/PO.24.00187

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Article

Comparing the Diagnostic Yield of Germline Exome Versus Panel Sequencing in the Diverse Population of the Texas KidsCanSeq Pediatric Cancer Study.

JCO precision oncology - 1 Sept 2024

Desrosiers-Battu Lauren R, Wang Tao, Reuther Jacquelyn, Miles George, Dai Hongzheng, Jo Eunji, Russell Heidi, Raesz-Martinez Robin, Recinos Alva, Gutierrez Stephanie, Thomas Amy, Berenson Emily, Corredor Jessica, Nugent Kimberly, Wyatt Castillo Rachel, Althaus Rebecca, Littlejohn Rebecca, Gessay Shawn, Tomlinson Gail, Gill Jonathan, Bernini Juan Carlos, Vallance Kelly, Griffin Timothy, Scollon Sarah, Lin Frank Y, Eng Christine, Kulkarni Shashikant, Hilsenbeck Susan G, Roy Angshumoy, McGuire Amy L, Parsons D Williams, Plon Sharon E

Abstract excerpt

PURPOSE: To evaluate the relative diagnostic yield of clinical germline genomic tests in a diverse pediatric cancer population. PATIENTS AND METHODS: The KidsCanSeq study enrolled pediatric cancer patients across six sites in Texas. Germline analysis included both exome sequencing and a therapy-focused pediatric cancer gene panel. The results were categorized by participants demographics, the presence of...

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PMID: 39259914
DOI: 10.1200/PO.24.00187
PMCID: PMC11392521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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