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Clinical Impact of Constitutional Genomic Testing on Current Breast Cancer Care.

Clinical oncology (Royal College of Radiologists (Great Britain)) - 1 Feb 2025

Cheah W, Cutress R I, Eccles D, Copson E

Abstract excerpt

The most commonly diagnosed cancer in women worldwide is cancer of the breast. Up to 20% of familial cases are attributable to pathogenic mutations in high-penetrance (BReast CAncer gene 1 [BRCA1], BRCA2, tumor protein p53 [TP53], partner and localizer of breast cancer 2 [PALB2]) or moderate-penetrance (checkpoint kinase 2 [CHEK2], Ataxia-telangiectasia mutated [ATM], RAD51C, RAD51D) breast-cancer-predisposing...

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Breast Neoplasms
CHEK2 gene
NHS gene
PALB2 gene
TP53 gene
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Testing

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Identifiers

PMID: 39242249
DOI: 10.1016/j.clon.2024.08.006

Genes

ATM
BRCA1
BRCA2
CHEK2
NHS
PALB2
RAD51C
RAD51D
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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