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Article

Genetic variants in FCGR2A, PTPN2, VDR as predictive signatures of aggressive phenotypes in cerebral cavernous malformation.

Gene - 15 Jan 2025

Galvão Gustavo F, Trefilio Luisa M, Salvio Andreza L, da Silva Elielson V, Alves-Leon Soniza V, Fontes-Dantas Fabrícia L, de Souza Jorge M

Abstract excerpt

OBJECTIVE: The biological behavior of Cerebral Cavernous Malformation (CCM) is still controversial, lacking a clear-cut signature for a mechanistic explanation of lesion aggressiveness. In this study, we evaluated the predictive capacity of genetic variants concerning the aggressive behavior of CCM and their implications in biological processes. METHODS: We genotyped the variants in VDRrs7975232, VDRrs731236,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39236970
DOI: 10.1016/j.gene.2024.148918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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