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Genetic Polymorphisms of COL1A1 Promoter Region (rs1800012) and TGFB1 Signal Peptide (rs1800471): Role in Cervical Insufficiency Susceptibility?

Reproductive sciences (Thousand Oaks, Calif.) - 1 Oct 2024

Gulucu Selim, Onal Mesut, Karakus Nevin

Abstract excerpt

A structural or functional cervix problem prevents a woman from carrying a full-term pregnancy, which leads to the disease known as cervical insufficiency. Cervical insufficiency is partially inherited, and in certain situations, variations in genes related to connective tissue metabolism may be involved. The main objective of this investigation was to describe the collagen type I alpha 1 chain (COL1A1) gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39210235
DOI: 10.1007/s43032-024-01684-8

Genes

COL1A1
TGFB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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