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Interleukin-1 Gene Cluster Polymorphisms and its Haplotypes may Predict the Risk to Develop Cervical Cancer in Tunisia.

Pathology oncology research : POR - 1 Sept 2015

Zidi Sabrina, Sghaier Ikram, Zouidi Ferjeni, Benahmed Amira, Stayoussef Mouna, Kochkar Radhia, Gazouani Ezzedine, Mezlini Amel, Yacoubi-Loueslati Besma

Abstract excerpt

Our study aimed to evaluate the association between IL-1α (4845 G/T), IL-1β (-511C/T) and IL-1RN (VNTR) polymorphisms and risk of cervical cancer. This case-control study investigates three polymorphisms in 130 patients and 260 controls by PCR-restriction fragment length polymorphism (RFLP). The IL-1RN (VNTR) A1/A3 genotype appear as a cervical cancer risk factor (p = 0.048; OR = 2.92; 95 % CI = 1.00-8.74),...

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PMID: 25925136
DOI: 10.1007/s12253-015-9941-8

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