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Custom target-sequencing in triple-negative and luminal breast cancer from young Brazilian patients.

Clinics (Sao Paulo, Brazil) - 1 Jan 2024

Serio Pedro Adolpho de Menezes Pacheco, Saccaro Daniela Marques, de Gouvêa Ana Carolina Ribeiro Chaves, Encinas Giselly, Maistro Simone, Pereira Gláucia Fernanda de Lima, Rocha Vinícius Marques, de Souza Larissa Dias, da Silva Viviane Jennifer, Katayama Maria Lucia Hirata, Folgueira Maria Aparecida Azevedo Koike

Abstract excerpt

OBJECTIVES: To identify somatic mutations in tumors from young women with triple-negative or luminal breast cancer, through targeted sequencing and to explore the cancer driver potential of these gene variants. METHODS: A customized gene panel was assembled based on data from previous sequencing studies of breast cancer from young women. Triple-negative and luminal tumors and paired blood samples from young...

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Identifiers

PMID: 39208653
DOI: 10.1016/j.clinsp.2024.100479
PMCID: PMC11399600

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