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Article

Novel Insights into Hb Shaare Zedek Associated with β0-Thalassemia: Molecular Characteristics, Genetic Origin and Diagnostic Approaches.

International journal of molecular sciences - 6 Aug 2024

Satthakarn Surada, Srisuwan Wibhasiri, Kunyanone Naowarat, Panyasai Sitthichai

Abstract excerpt

Hemoglobin Shaare Zedek (Hb SZ) is a rare structural α-Hb variant. Characterizing its genotype-phenotype relationship and genetic origin enhances diagnostic and clinical management insights. We studied a proband and six family members using high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), PCR, and sequencing to analyze α- and β-globin genes and α-globin haplotypes. Pathogenicity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39201263
DOI: 10.3390/ijms25168578
PMCID: PMC11354257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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