Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias.

doi:10.1038/s44161-023-00419-3

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Article

Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias.

Nature cardiovascular research - 1 Feb 2024

Selvakumar Dinesh, Clayton Zoe E, Prowse Andrew, Dingwall Steve, Kim Sul Ki, Reyes Leila, George Jacob, Shah Haisam, Chen Siqi, Leung Halina H L, Hume Robert D, Tjahjadi Laurentius, Igoor Sindhu, Skelton Rhys J P, Hing Alfred, Paterson Hugh, Foster Sheryl L, Pearson Lachlan, Wilkie Emma, Marcus Alan D, Jeyaprakash Prajith, Wu Zhixuan, Chiu Han Shen, Ongtengco Cherica Felize J, Mulay Onkar, McArthur Jeffrey R, Barry Tony, Lu Juntang, Tran Vu, Bennett Richard, Kotake Yasuhito, Campbell Timothy, Turnbull Samual, Gupta Anunay, Nguyen Quan, Ni Guiyan, Grieve Stuart M, Palpant Nathan J, Pathan Faraz, Kizana Eddy, Kumar Saurabh, Gray Peter P, Chong James J H

Abstract excerpt

Preclinical data have confirmed that human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) can remuscularize the injured or diseased heart, with several clinical trials now in planning or recruitment stages. However, because ventricular arrhythmias represent a complication following engraftment of intramyocardially injected PSC-CMs, it is necessary to provide treatment strategies to control or prevent...

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PMID: 39196193
DOI: 10.1038/s44161-023-00419-3
PMCID: PMC11358004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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