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Article

[Advance in HIF expression and immune microenvironment in pseudohypoxic HNPGL].

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery - 1 Sept 2024

Zhang Boya, Lou Zihan, Wang Jingjing, Hu Yibing, Chen Zhengnong

Abstract excerpt

This article systematically reviewed the pathological features, molecular mechanisms, and tumor microenvironment of head and neck paraganglioma（HNPGL）, with a focus on pseudohypoxic HNPGL. It was demonstrated that pseudohypoxic HNPGL mainly involves multiple gene mutations, such as SDHx and VHL/EPAS1, which affect the stability and activity of HIF protein and exacerbate the development of the tumor. Meanwhile,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39193740
DOI: 10.13201/j.issn.2096-7993.2024.09.009

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