Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pseudohypoxia in paraganglioma and pheochromocytoma is associated with an immunosuppressive phenotype.

The Journal of pathology - 1 Jan 2023

Celada Lucía, Cubiella Tamara, San-Juan-Guardado Jaime, Gutiérrez Gala, Beiguela Brenda, Rodriguez Raúl, Poch María, Astudillo Aurora, Grijalba Ana, Sánchez-Sobrino Paula, Tous Maria, Navarro Elena, Serrano Teresa, Paja Miguel, Valdés Nuria, Chiara María-Dolores

Abstract excerpt

Metastatic pheochromocytoma and paraganglioma (PPGL) have poor prognosis and limited therapeutic options. The recent advent of immunotherapies showing remarkable clinical efficacies against various cancer types offers the possibility of novel opportunities also for metastatic PPGL. Most PPGLs are pathogenically linked to inactivating mutations in genes encoding different succinate dehydrogenase (SDH) subunits....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Gland Neoplasms
Share to B7-H1 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cancer, Hypoxia, and Metabolism

Share to Neuroblastoma Research and Treatments

Share to Paraganglioma

Share to Phenotype

Share to Pheochromocytoma

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 36314599
DOI: 10.1002/path.6026
PMCID: PMC10107524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pseudohypoxia in paraganglioma and pheochromocytoma is associated with an immunosuppressive phenotype.PMID 36314599Read ↗

The connection between tricarboxylic acid cycle enzyme mutations and pseudohypoxic signaling in pheochromocytoma and paraganglioma.Semantic proximity Read ↗

Transcriptional Subtypes on Immune Microenvironment and Predicting Postoperative Recurrence and Metastasis in Pheochromocytoma and ParagangliomaSemantic proximity Read ↗

New insights on the pathogenesis of paraganglioma and pheochromocytomaSemantic proximity Read ↗

Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas.Semantic proximity Read ↗

Cytoplasmic HIF-2α correlates to proliferation and predicts worse outcome in sympathetic paragangliomaSemantic proximity Read ↗

[Advance in HIF expression and immune microenvironment in pseudohypoxic HNPGL].Semantic proximity Read ↗

Hypoxia-Inducible Factor 2α Mutation-Related Paragangliomas Classify as Discrete Pseudohypoxic Subcluster.Semantic proximity Read ↗

Epigenetic and metabolic reprogramming of SDH-deficient paragangliomasSemantic proximity Read ↗

Insights into Mechanisms of Pheochromocytomas and Paragangliomas Driven by Known or New Genetic DriversSemantic proximity Read ↗

Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction.Semantic proximity Read ↗

Genetic and Molecular Biomarkers in Aggressive Pheochromocytomas and Paragangliomas.Semantic proximity Read ↗

The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/ParagangliomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.