Clinical phenotyping uncovers heterogeneous associations between corticosteroid treatment and survival in critically ill COVID-19 patients.

doi:10.1007/s00134-024-07593-3

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Clinical phenotyping uncovers heterogeneous associations between corticosteroid treatment and survival in critically ill COVID-19 patients.

Intensive care medicine - 1 Nov 2024

Bruse Niklas, Motos Anna, van Amstel Rombout, de Bie Eckart, Kooistra Emma J, Jansen Aron, van Lier Dirk, Kennedy Jason, Schwarzkopf Daniel, Thomas-Rüddel Daniel, Bermejo-Martin Jesus F, Barbe Ferran, de Keizer Nicolette F, Bauer Michael, van der Hoeven Johannes G, Torres Antoni, Seymour Christopher, van Vught Lonneke, Pickkers Peter, Kox Matthijs

Abstract excerpt

PURPOSE: Disease heterogeneity in coronavirus disease 2019 (COVID-19) may render the current one-size-fits-all treatment approach suboptimal. We aimed to identify and immunologically characterize clinical phenotypes among critically ill COVID-19 patients, and to assess heterogeneity of corticosteroid treatment effect. METHODS: We applied consensus k-means clustering on 21 clinical parameters obtained within 24 h...

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Identifiers

PMID: 39186112
DOI: 10.1007/s00134-024-07593-3
PMCID: PMC11541258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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