Article
Evolution of SARS-CoV-2 in the murine central nervous system drives viral diversification.
Nature microbiology - 1 Sept 2024
Class Jacob, Simons Lacy M, Lorenzo-Redondo Ramon, Achi Jazmin Galván, Cooper Laura, Dangi Tanushree, Penaloza-MacMaster Pablo, Ozer Egon A, Lutz Sarah E, Rong Lijun, Hultquist Judd F, Richner Justin M
Abstract excerpt
Severe coronavirus disease 2019 and post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are associated with neurological complications that may be linked to direct infection of the central nervous system (CNS), but the selective pressures ruling neuroinvasion are poorly defined. Here we assessed SARS-CoV-2 evolution in the lung versus CNS of infected mice. Higher levels...
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