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C188-9 reduces patient-specific primary breast cancer cells proliferation at the low, clinic-relevant concentration

22 Aug 2024

Abstract excerpt

OBJECTIVES: STAT3 is a transcriptional activator of breast cancer oncogenes, suggesting that it could be a potential therapeutic target for breast cancer. Therefore, this study investigated the potential application of C188-9, a STAT3 signal pathway inhibitor, in the treatment of breast cancer through a novel pre-clinical platform with patient-specific primary cells (PSPCs). METHODS: PSPCs were isolated from...

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PMID: 39174945
DOI: 10.1186/s12967-024-05542-8

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