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Article

FGF and PI3 kinase signaling pathways antagonistically modulate sex muscle differentiation in C. elegans.

Development (Cambridge, England) - 1 Nov 2004

Sasson Isaac E, Stern Michael J

Abstract excerpt

Myogenesis in vertebrate myocytes is promoted by activation of the phosphatidyl-inositol 3'-kinase (PI3 kinase) pathway and inhibited by fibroblast growth factor (FGF) signaling. We show that hyperactivation of the Caenorhabditis elegans FGF receptor, EGL-15, similarly inhibits the differentiation of the hermaphrodite sex muscles. Activation of the PI3 kinase signaling pathway can partially suppress this...

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Identifiers

PMID: 15469970
DOI: 10.1242/dev.01423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FGF and PI3 kinase signaling pathways antagonistically modulate sex muscle differentiation in C. elegans.PMID 15469970Read ↗

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