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IL-1β mediates Candida tropicalis-induced immunosuppressive function of MDSCs to foster colorectal cancer

21 Aug 2024

Abstract excerpt

BACKGROUND: There is increasing evidence that gut fungi dysbiosis plays a crucial role in the development and progression of colorectal cancer (CRC). It has been reported that gut fungi exacerbate the severity of CRC by regulating tumor immunity. Our previous studies have shown that the opportunistic pathogenic fungal pathogen, Candida tropicalis (C. tropicalis) promotes CRC progression by enhancing the...

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PMID: 39164774
DOI: 10.1186/s12964-024-01771-y

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