Article
The CALR mutations enhance the expression of the immunosuppressive proteins GARP and LAP on peripheral blood lymphocytes through increased binding of activated platelets.
British journal of haematology - 1 Oct 2024
Holmström Morten Orebo, Ruders Josephine Hallundbæk, Riley Caroline Hasselbalch, Larsen Morten Kranker, Grauslund Jacob Handlos, Kjær Lasse, Skov Vibe, Ellervik Christina, Guo Belinda B, Linden Matthew, Hasselbalch Hans Carl, Andersen Mads Hald
Abstract excerpt
Recently, an antibody which inhibits the glycoprotein A repetitions predominant (GARP)-mediated release of active transforming growth factor beta (TGFβ) from the TGFβ propeptide latency-associated peptide (LAP) showed preclinical activity in a murine model of the chronic myeloproliferative neoplasms (MPN). Consequently, we investigated the expression of the immunosuppressive molecules LAP and GARP on peripheral...
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