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Article

Comprehensive database of HIV mutations selected during antiretroviral in vitro passage experiments.

Antiviral research - 1 Oct 2024

Tao Kaiming, Zhou Jinru, Nagarajan Pavithra, Tzou Philip L, Shafer Robert W

Abstract excerpt

BACKGROUND: In vitro passage experiments are crucial to the development of antiretroviral (ARV) drugs. METHODS: We created an online database containing data from 102 published studies in which HIV-1 or HIV-2 was cultured with increasing concentrations of the FDA-approved nucleoside RT inhibitors (NRTIs), nonnucleoside RT inhibitors (NNRTIs), integrase strand transfer inhibitors (INSTIs), protease inhibitors...

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Identifiers

PMID: 39154752
DOI: 10.1016/j.antiviral.2024.105988
PMCID: PMC11412686

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