Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of Dnajc21 leads to cytopenia and altered nucleotide metabolism in zebrafish.

Leukemia - 1 Oct 2024

Ketharnathan Sarada, Pokharel Sujata, Prykhozhij Sergey V, Cordeiro-Santanach Anna, Ban Kevin, Dogan Serkan, Hoang Huy-Dung, Liebman Mira F, Leung Elaine, Alain Tommy, Alecu Irina, Bennett Steffany A L, Čuperlović-Culf Miroslava, Dror Yigal, Berman Jason N

Abstract excerpt

Mutations in the DNAJC21 gene were recently described in Shwachman-Diamond syndrome (SDS), a bone marrow failure syndrome with high predisposition for myeloid malignancies. To study the underlying biology in hematopoiesis regulation and disease, we generated the first in vivo model of Dnajc21 deficiency using the zebrafish. Zebrafish dnajc21 mutants phenocopy key SDS patient phenotypes such as cytopenia, reduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to Hematopoiesis

Share to Nucleotides

Share to Tumor Suppressor Protein p53

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39138265
DOI: 10.1038/s41375-024-02367-8
PMCID: PMC11436362

Genes

DNAJC21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of Dnajc21 leads to cytopenia and altered nucleotide metabolism in zebrafish.PMID 39138265Read ↗

Shwachman-Diamond syndromes: clinical, genetic, and biochemical insights from the rare variants.Semantic proximity Read ↗

Refining the phenotype associated with biallelic DNAJC21 mutations.Semantic proximity Read ↗

DTYMK is essential for genome integrity and neuronal survival.Semantic proximity Read ↗

STING and VDAC inhibitors attenuate inflammation and ineffective erythropoiesis caused by an altered metabolome in the <i>Nan</i> (EKLF/E339D) mouse model of neonatal anemiaSemantic proximity Read ↗

DDX41 dissolves G-quadruplexes to maintain erythroid genome integrity and prevent cGAS-mediated cell deathSemantic proximity Read ↗

Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.Semantic proximity Read ↗

SBDS Gene Mutation Increases ROS Production and Causes DNA Damage as Well as Oxidation of Mitochondrial Membranes in the Murine Myeloid Cell Line 32Dcl3.Semantic proximity Read ↗

Cohesin rad21 mutation dysregulates erythropoiesis and granulopoiesis output within the whole kidney marrow of adult zebrafish.Semantic proximity Read ↗

DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cellsSemantic proximity Read ↗

DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells.Semantic proximity Read ↗

Biallelic mutations in DNAJC21 cause Shwachman-Diamond syndrome.Semantic proximity Read ↗

Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.