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Article

Balancing the efforts of chart review and gains in PRS prediction accuracy: An empirical study.

Journal of biomedical informatics - 1 Sept 2024

Lei Yuqing, Christian Naj Adam, Xu Hua, Li Ruowang, Chen Yong

Abstract excerpt

OBJECTIVE: Phenotypic misclassification in genetic association analyses can impact the accuracy of PRS-based prediction models. The bias reduction method proposed by Tong et al. (2019) has demonstrated its efficacy in reducing the effects of bias on the estimation of association parameters between genotype and phenotype while minimizing variance by employing chart reviews on a subset of the data for validating...

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Identifiers

PMID: 39134233
DOI: 10.1016/j.jbi.2024.104705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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