Article
Large-pore connexin hemichannels function like molecule transporters independent of ion conduction.
Proceedings of the National Academy of Sciences of the United States of America - 13 Aug 2024
Gaete Pablo S, Kumar Deepak, Fernandez Cynthia I, Valdez Capuccino Juan M, Bhatt Aashish, Jiang Wenjuan, Lin Yi-Chun, Liu Yu, Harris Andrew L, Luo Yun L, Contreras Jorge E
Abstract excerpt
Connexin hemichannels were identified as the first members of the eukaryotic large-pore channel family that mediate permeation of both atomic ions and small molecules between the intracellular and extracellular environments. The conventional view is that their pore is a large passive conduit through which both ions and molecules diffuse in a similar manner. In stark contrast to this notion, we demonstrate that...
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