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Article

Implication of KMT2C and TSC2 variants in the tumorigenesis of acquired cystic disease-associated renal cell carcinomas.

Annals of diagnostic pathology - 1 Dec 2024

Kojima Fumiyoshi, Matsuzaki Ibu, Musangile Fidele Yambayamba, Sagan Kanako, Mikasa Yurina, Iwamoto Ryuta, Kohjimoto Yasuo, Hara Isao, Murata Shin-Ichi

Abstract excerpt

In 2020, acquired cystic disease-associated renal cell carcinomas (ACD-RCCs) were reported to harbor KMT2C and TSC2 variants: however, their carcinogenic implication has not yet been reported. This study aimed to explore the variant features of KMT2C and TSC2 in ACD-RCC and their implication in ACD-RCC tumorigenesis. Eleven ACD-RCCs, 10 ACD-RCC-like cysts, and 18 background kidneys were retrieved. The background...

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PMID: 39089178
DOI: 10.1016/j.anndiagpath.2024.152364

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