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Article

LRPPRC and SLIRP synergize to maintain sufficient and orderly mammalian mitochondrial translation.

Nucleic acids research - 14 Oct 2024

Rubalcava-Gracia Diana, Bubb Kristina, Levander Fredrik, Burr Stephen P, August Amelie V, Chinnery Patrick F, Koolmeister Camilla, Larsson Nils-Göran

Abstract excerpt

In mammals, the leucine-rich pentatricopeptide repeat protein (LRPPRC) and the stem-loop interacting RNA-binding protein (SLIRP) form a complex in the mitochondrial matrix that is required throughout the life cycle of most mitochondrial mRNAs. Although pathogenic mutations in the LRPPRC and SLIRP genes cause devastating human mitochondrial diseases, the in vivo function of the corresponding proteins is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39087558
DOI: 10.1093/nar/gkae662
PMCID: PMC11472161

Genes

SLIRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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