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Article

Glutamate transporters are involved in direct inhibitory synaptic transmission in the vertebrate retina.

Open biology - 1 Jul 2024

Niklaus Stephanie, Glasauer Stella M K, Kovermann Peter, Farshori Kulsum F, Cadetti Lucia, Früh Simon, Rieser Nicolas N, Gesemann Matthias, Zang Jingjing, Fahlke Christoph, Neuhauss Stephan C F

Abstract excerpt

In the central nervous system of vertebrates, glutamate serves as the primary excitatory neurotransmitter. However, in the retina, glutamate released from photoreceptors causes hyperpolarization in post-synaptic ON-bipolar cells through a glutamate-gated chloride current, which seems paradoxical. Our research reveals that this current is modulated by two excitatory glutamate transporters, EAAT5b and EAAT7. In the...

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Identifiers

PMID: 39079673
DOI: 10.1098/rsob.240140
PMCID: PMC11288666

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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