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Increased oxygen stimulation promotes chemoresistance and phenotype shifting through PLCB1 in gliomas.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Sept 2024

Ma Kang, Wang Shi, Ma Yingjie, Zeng Lan, Xu Kai, Mu Ning, Lai Ying, Shi Yaning, Yang Chuanyan, Chen Beike, Quan Yulian, Li Lan, Lu Yongling, Yang Yang, Liu Yan, Hu Rong, Wang Xiaoming, Chen Yujie, Bian Xiuwu, Feng Hua, Li Fei, Chen Tunan

Abstract excerpt

Gliomas, the most common CNS (central nerve system) tumors, face poor survival due to severe chemoresistance exacerbated by hypoxia. However, studies on whether altered hypoxic conditions benefit for chemo-sensitivity and how gliomas react to increased oxygen stimulation are limited. In this study, we demonstrated that increased oxygen stimulation promotes glioma growth and chemoresistance. Mechanically,...

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Source

Identifiers

PMID: 39053384
DOI: 10.1016/j.drup.2024.101113

Genes

PLCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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