Inflammatory bowel disease and osteoporosis: Common genetic effects, pleiotropy, and causality.

Abstract excerpt

INTRODUCTION: Previous studies have shown that inflammatory bowel disease (IBD) is associated with osteoporosis (OP) and bone mineral density (BMD), but the underlying genetic mechanisms are unclear. Our study wanted to explore the genetic and causal relationship between IBD and OP. MATERIALS AND METHODS: Based on large-scale genome-wide association summary statistics and individual-level datasets (i.e., the UK...

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• Bone Density
• Genetic Pleiotropy
• Genome-Wide Association Study
• Inflammatory Bowel Diseases
• Linkage Disequilibrium