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Article

Blood Tumor Mutational Burden Alone Is Not a Good Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Patients With Gastrointestinal Tumors.

Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000

Yu James, Park Robin, Miao Ruoyu, Imanirad Iman, Shahzad Moazzam, Laborde Jose M, Knepper Todd C, Walko Christine M, Kim Richard

Abstract excerpt

There has been a controversy about the predictive value of tissue-TMB-H for immune checkpoint inhibitors (ICIs) with limited data regarding blood-TMB (bTMB) in GI tumors. We aim to evaluate the predictive value of bTMB compared with MSI-H in GI tumors. Patients with unresectable/metastatic GI cancer, harboring either MSS with bTMB-H (≥10 mut/Mb) or dMMR/MSI-H who received ICI were included. We compared ICIs'...

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Identifiers

PMID: 39012081
DOI: 10.1097/CJI.0000000000000532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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