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Article

Preliminary investigation of potential links between pigmentation variants and opioid analgesic effectiveness in horses during cerebrospinal fluid centesis.

BMC veterinary research - 12 Jul 2024

Bacon Elouise K, Donnelly Callum G, Bellone Rebecca R, Haase Bianca, Finno Carrie J, Velie Brandon D

Abstract excerpt

BACKGROUND: The pleiotropic effects of the melanocortin system show promise in overcoming limitations associated with large variations in opioid analgesic effectiveness observed in equine practice. Of particular interest is variation in the melanocortin-1-receptor (MC1R) gene, which dictates pigment type expression through its epistatic interaction with the agouti signalling protein (ASIP) gene. MC1R has...

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Share to Agouti Signaling Protein
Share to Analgesics, Opioid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Receptor, Melanocortin, Type 1

Source

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Identifiers

PMID: 38997753
DOI: 10.1186/s12917-024-04139-z
PMCID: PMC11245827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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