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Exosomes derived from human urine–derived stem cells ameliorate IL-1β-induced intervertebral disk degeneration

12 Jul 2024

Abstract excerpt

BACKGROUND: Human intervertebral disk degeneration (IVDD) is a sophisticated degenerative pathological process. A key cause of IVDD progression is nucleus pulposus cell (NPC) degeneration, which contributes to excessive endoplasmic reticulum stress in the intervertebral disk. However, the mechanisms underlying IVDD and NPC degeneration remain unclear. METHODS: We used interleukin (IL)-1β stimulation to establish...

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PMID: 38997667
DOI: 10.1186/s12891-024-07636-2

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