Article
Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants.
Nature neuroscience - 1 Dec 2019
Satterstrom F Kyle, Walters Raymond K, Singh Tarjinder, Wigdor Emilie M, Lescai Francesco, Demontis Ditte, Kosmicki Jack A, Grove Jakob, Stevens Christine, Bybjerg-Grauholm Jonas, Bækvad-Hansen Marie, Palmer Duncan S, Maller Julian B, Nordentoft Merete, Mors Ole, Robinson Elise B, Hougaard David M, Werge Thomas M, Bo Mortensen Preben, Neale Benjamin M, Børglum Anders D, Daly Mark J
Abstract excerpt
The exome sequences of approximately 8,000 children with autism spectrum disorder (ASD) and/or attention deficit hyperactivity disorder (ADHD) and 5,000 controls were analyzed, finding that individuals with ASD and individuals with ADHD had a similar burden of rare protein-truncating variants in evolutionarily constrained genes, both significantly higher than controls. This motivated a combined analysis across...
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