Comparison of Primary and Metastatic Fumarate Hydratase-Deficient Renal Cell Carcinomas Documents Morphologic Divergence and Potential Diagnostic Pitfall With Peritoneal Mesothelioma.

doi:10.1016/j.modpat.2024.100561

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Article

Comparison of Primary and Metastatic Fumarate Hydratase-Deficient Renal Cell Carcinomas Documents Morphologic Divergence and Potential Diagnostic Pitfall With Peritoneal Mesothelioma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2024

Caliò Anna, Marletta Stefano, Stefanizzi Lavinia, Marcolini Lisa, Rotellini Matteo, Serio Gabriella, Bariani Elena, Vicentini Caterina, Pedron Serena, Martelli Filippo M, Antonini Pietro, Brunelli Matteo, Martignoni Guido

Abstract excerpt

Fumarate hydratase (FH)-deficient renal cell carcinomas are rare neoplasms characterized by wide morphologic heterogeneity and pathogenetic mutations in the FH gene. They often show aggressive behavior with rapid diffusion to distant organs, so novel therapeutic scenarios have been explored, including EGFR inhibitors and PD-L1 expression for targeted immunotherapy. Herein, we investigated a series of 11 primary...

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Identifiers

PMID: 38996839
DOI: 10.1016/j.modpat.2024.100561

Genes

FH
EGFR
PAX8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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