Article
Pattern multiplicity and fumarate hydratase (FH)/S-(2-succino)-cysteine (2SC) staining but not eosinophilic nucleoli with perinucleolar halos differentiate hereditary leiomyomatosis and renal cell carcinoma-associated renal cell carcinomas from kidney tumors without FH gene alteration.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2018
Muller Marie, Guillaud-Bataille Marine, Salleron Julia, Genestie Catherine, Deveaux Sophie, Slama Abdelhamid, de Paillerets Brigitte Bressac, Richard Stéphane, Benusiglio Patrick R, Ferlicot Sophie
Abstract excerpt
Hereditary leiomyomatosis and renal cell carcinoma syndrome is characterized by an increased risk of agressive renal cell carcinoma, often of type 2 papillary histology, and is caused by FH germline mutations. A prominent eosinophilic macronucleolus with a perinucleolar clear halo is distinctive of hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma according to the 2012...
Topics
- Carcinoma, Renal Cell
- Diagnosis, Differential
- Fumarate Hydratase
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Kidney Neoplasms