Human platelet lysate supports SH-SY5Y neuroblastoma cell proliferation and differentiation into a dopaminergic-like neuronal phenotype under xenogeneic-free culture conditions.

doi:10.1002/biot.202400068

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Human platelet lysate supports SH-SY5Y neuroblastoma cell proliferation and differentiation into a dopaminergic-like neuronal phenotype under xenogeneic-free culture conditions.

Biotechnology journal - 1 Jul 2024

Ribeiro Miguel, Campos Jonas, Pinho Tiffany S, Sampaio-Marques Belém, Barata-Antunes Sandra, Cibrão Jorge Ribeiro, Araújo Ricardo, Duarte-Silva Sara, Moreira Elsa, Sousa Rui A, Costa Pedro M, Salgado António J

Abstract excerpt

SH-SY5Y is a human neuroblastoma cell line that can be differentiated into several neuronal phenotypes, depending on culture conditions. For this reason, this cell line has been widely used as an in vitro model of neurodegenerative conditions, such as Parkinson's disease (PD). However, most studies published to date used fetal bovine serum (FBS) as culture medium supplement for SH-SY5Y cell differentiation. We...

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