Pre-clinical phaeochromocytoma and paraganglioma models: Cell lines, animal models, and a human primary culture model

Abstract excerpt

While the establishment of human phaeochromocytoma and paraganglioma (PPGL) cell lines has proven to be particularly difficult over several decades of research, there are other reliable pre-clinical PPGL models currently available. This review provides a summary of these models, together with our recently established personalised drug screening platform using patient-derived PPGL primary cultures. Such currently...

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