Article
Erythroid-intrinsic activation of TLR8 impairs erythropoiesis in inherited anemia.
Nature communications - 6 Jul 2024
Liang Jing, Wan Yang, Gao Jie, Zheng Lingyue, Wang Jingwei, Wu Peng, Li Yue, Wang Bingrui, Wang Ding, Ma Yige, Shen Biao, Lv Xue, Wang Di, An Na, Ma Xiaoli, Geng Guangfeng, Tong Jingyuan, Liu Jinhua, Chen Guo, Gao Meng, Kurita Ryo, Nakamura Yukio, Zhu Ping, Yin Hang, Zhu Xiaofan, Shi Lihong
Abstract excerpt
Inherited non-hemolytic anemia is a group of rare bone marrow disorders characterized by erythroid defects. Although concerted efforts have been made to explore the underlying pathogenetic mechanisms of these diseases, the understanding of the causative mutations are still incomplete. Here we identify in a diseased pedigree that a gain-of-function mutation in toll-like receptor 8 (TLR8) is implicated in inherited...
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