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Comparison of primary and passaged tumor cell cultures and their application in personalized medicine

17 Jun 2024

Abstract excerpt

Passaged cell lines represent currently an integral component in various studies of malignant neoplasms. These cell lines are utilized for drug screening both in monolayer cultures or as part of three-dimensional (3D) tumor models. They can also be used to model the tumor microenvironment in vitro and in vivo through xenotransplantation into immunocompromised animals. However, immortalized cell lines have some...

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PMID: 38966179
DOI: 10.37349/etat.2024.00237

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