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Article

Molecular Mechanism Underlying Resistance Variation to the Novel Agrochemical Quinofumelin in Fusarium graminearum.

Molecular plant pathology - 1 Apr 2026

Yin Xiaoru, Gao Xinlong, Liu Xudong, Zhang Ziyang, Xiu Qian, Ren Fuhao, Zhang Jie, Zhou Mingguo, Duan Yabing

Abstract excerpt

Quinofumelin, a quinoline-based fungicide, demonstrated potent antifungal activity against Fusarium graminearum, the pathogen responsible for Fusarium head blight (FHB) in wheat. Previously, we elucidated that quinofumelin targets dihydroorotate dehydrogenase (DHODH), an indispensable enzyme in the de novo pyrimidine biosynthesis pathway. To explore its resistance mechanism, five FgDHODHII site-directed mutants...

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Identifiers

PMID: 41968689
DOI: 10.1111/mpp.70261
PMCID: PMC13071355

Genes

DHODH

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