Article
The role of immune checkpoint inhibitors: Variable number of tandem repeat (VNTR) polymorphism in the second exon of the P-selectin glycoprotein ligand-1 (PSGL-1) gene polymorphism in multiple myeloma.
Molecular carcinogenesis - 1 Oct 2024
Oyaci Yasemin, Pehlivan Mustafa, Pehlivan Sacide, Cinli Tahir Alper, Tuncel Fatima Ceren, Ertas Elif, Serin Istemi
Abstract excerpt
Somatic mutations and polymorphisms may play a role in multiple myeloma (MM) susceptibility and survival. One of the immune checkpoint inhibitors is P-selectin glycoprotein ligand-1 (PSGL-1); the majority of tumor-infiltrating leukocytes express PSGL-1, causing T cell and immune inhibition via PSGL-1 mediator molecules. We aimed to investigate the effect of variable number of tandem repeat (VNTR) polymorphism in...
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