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Article

Variations in suppressor molecule ctla-4 gene are related to susceptibility to multiple myeloma in a polish population.

Pathology oncology research : POR - 1 Apr 2012

Karabon Lidia, Pawlak-Adamska Edyta, Tomkiewicz Anna, Jedynak Anna, Kielbinski Marek, Woszczyk Dariusz, Potoczek Stanisław, Jonkisz Anna, Kuliczkowski Kazimierz, Frydecka Irena

Abstract excerpt

Various phenotype and functional T-cell abnormalities are observed in multiple myeloma (MM) patients. The aim of this study was to investigate the association between polymorphisms in the gene encoding cytotoxic T-lymphocyte antigen-4 (CTLA-4), a negative regulator of the T-lymphocyte immune response and susceptibility to multiple myeloma in a Polish population. Two hundred MM patients and 380 healthy subjects...

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PMID: 21744007
DOI: 10.1007/s12253-011-9431-6
PMCID: PMC3313022

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