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Article

N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma.

Cancer research communications - 1 Jul 2024

Geroyska Sofia, Mejia Isabel, Chan Alfred A, Navarrete Marian, Pandey Vijaya, Kharpatin Samuel, Noguti Juliana, Wang Feng, Srole Daniel, Chou Tsui-Fen, Wohlschlegel James, Nemeth Elizabeta, Damoiseaux Robert, Shackelford David B, Lee Delphine J, Díaz Begoña

Abstract excerpt

Myristoylation is a type of protein acylation by which the fatty acid myristate is added to the N-terminus of target proteins, a process mediated by N-myristoyltransferases (NMT). Myristoylation is emerging as a promising cancer therapeutic target; however, the molecular determinants of sensitivity to NMT inhibition or the mechanism by which it induces cancer cell death are not completely understood. We report...

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Identifiers

PMID: 38949950
DOI: 10.1158/2767-9764.CRC-23-0428
PMCID: PMC11270646

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