Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of polygenic scores of telomere length alleles on telomere length in newborns and parents.

Aging cell - 1 Sept 2024

Lee Yunsung, Jugessur Astanand, Gjessing Håkon K, Harris Jennifer R, Susser Ezra, Magnus Per, Aviv Abraham

Abstract excerpt

In adults, polygenic scores (PGSs) of telomere length (TL) alleles explain about 4.5% of the variance in TL, as measured by quantitative polymerase chain reaction (qPCR). Yet, these PGSs strongly infer a causal role of telomeres in aging-related diseases. To better understand the determinants of TL through the lifespan, it is essential to examine to what extent these PGSs explain TL in newborns. This study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Infant, Newborn
Share to Multifactorial Inheritance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Parents

Share to Telomere

Share to Telomere Homeostasis

Source

Open in PubMed Open full text

Identifiers

PMID: 38943263
DOI: 10.1111/acel.14241
PMCID: PMC11488311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of polygenic scores of telomere length alleles on telomere length in newborns and parents.PMID 38943263Read ↗

The known genetic loci for telomere length may be involved in the modification of telomeres length after birth.Semantic proximity Read ↗

Telomere length is paternally inherited and is associated with parental lifespanSemantic proximity Read ↗

Polygenic basis and biomedical consequences of telomere length variationSemantic proximity Read ↗

Involvement of Inheritance in Determining Telomere Length beyond Environmental and Lifestyle FactorsSemantic proximity Read ↗

Variability in newborn telomere length is explained by inheritance and intrauterine environmentSemantic proximity Read ↗

Newborn telomere length predicts later life telomere length: Tracking telomere length from birth to child- and adulthoodSemantic proximity Read ↗

Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human DiseaseSemantic proximity Read ↗

Parental Genetics Communicate with Intrauterine Environment to Reprogram Newborn Telomeres and Immunity.Semantic proximity Read ↗

Telomere length determinants in childhoodSemantic proximity Read ↗

Unraveling the causal genes and transcriptomic determinants of human telomere lengthSemantic proximity Read ↗

Association between genetic risk score for telomere length and risk of breast cancer.Semantic proximity Read ↗

The contribution of parent-to-offspring transmission of telomeres to the heritability of telomere length in humansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.